Publication:20201201183046
From Bioinformatics Core Wiki
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| URL | https://pubmed.ncbi.nlm.nih.gov/33046098/ |
| Title | The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing
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| Authors | Lorena Zubovic, Silvano Piazza, Toma Tebaldi, Luca Cozzuto, Giuliana Palazzo, Viktoryia Sidarovich, Veronica De Sanctis, Roberto Bertorelli, Tim Lammens, Mattias Hofmans, Barbara De Moerloose, Julia Ponomarenko, Martina Pigazzi, Riccardo Masetti, Cristina Mecucci, Giuseppe Basso, Paolo Macchi |
| Date | 2020-10-12
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| Publisher | Journal of Hematology & Oncology |
| DOI | 10.1186/s13045-020-00974-3 |
| Tag | Child, Gene Expression Profiling, Humans, Myelodysplastic Syndromes, Sequence Analysis, RNA, Transcriptome, Differentially expressed genes, Myelodysplastic syndrome, Pediatrics, Transcriptome |
Abstract:
Pediatric myelodysplastic syndrome (PMDS) is a very rare and still poorly characterized disorder. In this work, we identified novel potential targets of PMDS by determining genes with aberrant expression, which can be correlated with PMDS pathogenesis. We identified 291 differentially expressed genes (DEGs) in PMDS patients, comprising genes involved in the regulation of apoptosis and the cell cycle, ribosome biogenesis, inflammation and adaptive immunity. Ten selected DEGs were then validated, confirming the sequencing data. These DEGs will potentially represent new molecular biomarkers and therapeutic targets for PMDS.
Pediatric myelodysplastic syndrome (PMDS) is a very rare and still poorly characterized disorder. In this work, we identified novel potential targets of PMDS by determining genes with aberrant expression, which can be correlated with PMDS pathogenesis. We identified 291 differentially expressed genes (DEGs) in PMDS patients, comprising genes involved in the regulation of apoptosis and the cell cycle, ribosome biogenesis, inflammation and adaptive immunity. Ten selected DEGs were then validated, confirming the sequencing data. These DEGs will potentially represent new molecular biomarkers and therapeutic targets for PMDS.
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