Publication:20200414081511
From Bioinformatics Core Wiki
| Publication | |
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| URL | https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-020-01759-x |
| Title | The penile microbiota of Black South African men: relationship with human papillomavirus and HIV infection
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| Authors | Harris Onywera, Anna-Lise Williamson, Luca Cozzuto, Sarah Bonnin, Zizipho Z. A. Mbulawa, David Coetzee, Julia Ponomarenko, Tracy L. Meiring |
| Date | 2020-04-06
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| Publisher | BMC Microbiology |
| DOI | 10.1186/s12866-020-01759-x |
| Tag | Microbiota, Penile, Human papillomavirus (HPV), HIV |
Abstract:
To date, the microbiota of the human penis has been studied mostly in connection with circumcision, HIV risk and female partner bacterial vaginosis (BV). These studies have shown that male circumcision reduces penile anaerobic bacteria, that greater abundance of penile anaerobic bacteria is correlated with increased cytokine levels and greater risk of HIV infection, and that the penile microbiota is an important harbour for BV-associated bacteria. While circumcision has been shown to significantly reduce the risk of acquiring human papillomavirus (HPV) infection, the relationship of the penile microbiota with HPV is still unknown. In this study, we examined the penile microbiota of HPV-infected men as well as the impact of HIV status.
To date, the microbiota of the human penis has been studied mostly in connection with circumcision, HIV risk and female partner bacterial vaginosis (BV). These studies have shown that male circumcision reduces penile anaerobic bacteria, that greater abundance of penile anaerobic bacteria is correlated with increased cytokine levels and greater risk of HIV infection, and that the penile microbiota is an important harbour for BV-associated bacteria. While circumcision has been shown to significantly reduce the risk of acquiring human papillomavirus (HPV) infection, the relationship of the penile microbiota with HPV is still unknown. In this study, we examined the penile microbiota of HPV-infected men as well as the impact of HIV status.
| Annotation | This paper is the result of the six-months internship with us of Harris Onywera from the University Cape Town, South Africa, on the CRG-Novartis-Africa Mobility Programme. The findings indicate that there is a strong link between the penile microbiota and viral STIs, specifically HIV and HPV. |
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