Publication:20161121154343

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Publication
URL http://www.ncbi.nlm.nih.gov/pubmed/22972935
Title Age-associated inflammation inhibits epidermal stem cell function

Authors Jason Doles, Mekayla Storer, Luca Cozzuto, Guglielmo Roma, William M. Keyes
Date 2012-10-01

Publisher Genes & Development
DOI 10.1101/gad.192294.112
Tag Aging, Animals, Cell Count, Cells, Cultured, Cytokines, Epidermal Cells, Epidermis, Hair Follicle, Homeostasis, Inflammation, Janus Kinases, Mice, Mice, Inbred C57BL, STAT3 Transcription Factor, Signal Transduction, Stem Cells



Abstract:
Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.


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