Publication:20161121153650

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Publication
URL http://www.ncbi.nlm.nih.gov/pubmed/25404137
Title SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos

Authors Damjan Cicin-Sain, Antonio Hermoso Pulido, Anton Crombach, Karl R. Wotton, Eva Jiménez-Guri, Jean-François Taly, Guglielmo Roma, Johannes Jaeger
Date 2015-1

Publisher Nucleic Acids Research
DOI 10.1093/nar/gku1142
Tag Animals, Databases, Genetic, Diptera, Drosophila melanogaster, Embryo, Nonmammalian, Gene Expression, Internet



Abstract:
We present SuperFly (http://superfly.crg.eu), a relational database for quantified spatio-temporal expression data of segmentation genes during early development in different species of dipteran insects (flies, midges and mosquitoes). SuperFly has a special focus on emerging non-drosophilid model systems. The database currently includes data of high spatio-temporal resolution for three species: the vinegar fly Drosophila melanogaster, the scuttle fly Megaselia abdita and the moth midge Clogmia albipunctata. At this point, SuperFly covers up to 9 genes and 16 time points per species, with a total of 1823 individual embryos. It provides an intuitive web interface, enabling the user to query and access original embryo images, quantified expression profiles, extracted positions of expression boundaries and integrated datasets, plus metadata and intermediate processing steps. SuperFly is a valuable new resource for the quantitative comparative study of gene expression patterns across dipteran species. Moreover, it provides an interesting test set for systems biologists interested in fitting mathematical gene network models to data. Both of these aspects are essential ingredients for progress toward a more quantitative and mechanistic understanding of developmental evolution.


Annotation SuperFly is a database for the comparative analysis of spatio-temporal gene expression patterns and regulation in dipteran species (flies, midges, and mosquitoes). It currently hosts data on the vinegar fly Drosophila melanogaster, the scuttle fly Megaselia abdita, and the moth midge Clogmia albipunctata. The BioCore designed and developed the database and the website to collect and visualize data.
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