Difference between revisions of "ProjectsBlocks"

|Description=CRISPETa is a web-tool for designing optimal pairs of sgRNAs for deletion of desired genomic regions; for example, lncRNAs. These target regions can be supplied in the BED or UCSC format. CRISPETa can be run on any number of targets - from one to thousands. At present, designs can be performed for five species, human, mouse, zebrafish, fruitfly, and worm. For more information and try the tool, visit [http://crispeta.crg.eu the CRISPETa website]. For curious, [https://en.wiktionary.org/wiki/crispeta ''crispeta'' means ''popcorn'', in Catalan]. The paper about CRISPETa was published in [http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005341 ''PLoS Comp. Biol.,'' 2017].

|Description=''Stick Out Your Tongue'', or ''Saca la Lengua'' in Spanish, is a citizen’s science project aiming to study the mouth’s microbiome of a large population of healthy young Spaniards and the relationship of microbiome profiles with environmental characteristics and lifestyle.  The Bioinformatics Core is involved in processing of the 16S rRNA sequencing data, obtaining microbiome abundance profiles for each individual, setting up a website for the data analysis competition, and teaching students and public about bioinformatics and microbiome analysis. For more information, visit [http://www.sacalalengua.org the Saca La Lengua public website].

|Description=The C syndrome, also known as the Opitz trigonocephaly syndrome, is a malformation syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features.  Although this syndrome was described in 1969 by [http://medicine.utah.edu/faculty/mddetail.php?facultyID=u0030518 Dr. John M. Opitz], the causative genes and the mode of inheritance are still unknown [http://www.ncbi.nlm.nih.gov/pubmed/26768331 by Urreizti ''et al''., 2016]. The Bioinformatics Core collaborates with the geneticists from the University of Barcelona, Drs. Daniel Grinberg  and Susana Balcells, and the Opitz C Association on analysis of the whole genomes of a patient and her parents to detect the putative causative mutations. The paper describing the results of sequencing and a ''de novo'' nonsense mutation in MAGEL2 in the affected patient was published in [http://www.nature.com/articles/srep44138 ''Scientific Reports,'' 2017.]

|Description=The Bioinformatics Core collaborates with Karl Wotton (Exeter University, UK) to assemble and annotate the genomes of three non-drosophilid diptera, ''Clogmia albipunctata'', ''Megaselia abdita'', and ''Episyrphus balteatus''. In collaboration with the group of Dr. Yogi Jaeger (CRG) we previously published the ''de novo'' transcriptomes of these flies  in [http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-123 ''BMC Genomics'', 2013].

|Description=SuperFly is a database for the comparative analysis of spatio-temporal gene expression patterns and regulation in dipteran species (flies, midges, and mosquitoes). It currently hosts data on three species, the vinegar fly ''Drosophila melanogaster'', the scuttle fly ''Megaselia abdita'', and the moth midge ''Clogmia albipunctata''. The Bionformatics Core developed the database and the website to collect and visualize data. For more information, visit [http://superfly.crg.eu/ SuperFly]. The database was published in [http://www.ncbi.nlm.nih.gov/pubmed/25404137 ''NAR'', 2015].

|Description=The Plant Resistance Genes database, [http://prgdb.crg.eu/wiki/Main_Page PRGdb], is a comprehensive resource on pathogen resistance genes (R-genes) in plants. Initiated in 2009, it currently provides data on 112 known and 104,310 putative R-genes in 233 plant species and conferring resistance to 122 pathogens. The Bionformatics Core participated in the project by redesigning the database website using the Semantic MediaWiki technologies. The databased was published in [http://nar.oxfordjournals.org/content/41/D1/D1167.long ''NAR'', 2013].

|Description=This project, aimed at deciphering the genome of the Iberian lynx, is a collaborative effort of six research centers in Spain. It is part of the Project Zero program FGCSIC 2010 in Endangered Species and funded by Banco Santander and Fundación General CSIC. The Bioinformatics Core was involved in generation of a first annotated draft of the genome. For more information, visit [http://www.lynxgenomics.eu the project website]. The results were published in [http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1090-1 ''Genome Biology'', 2016].

|Description=Melon ''Cucumis melo L.'' is a cucurbit with high economic impact and a well-known and appreciated product in Europe. Spain is the fifth world producer and the main exporter of melon.  To decipher the melon genome, the governmental foundation Genoma España funded the project ''MELONOMICS'', to which the Bioinformatics Core contributed by predicting small non-coding RNAs and pathogen resistant genes. For more information, visit [https://melonomics.net/ the MELONOMICS website].  The results were published in [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406823/ ''PNAS'', 2012].